Next Generation Sequencing Services

A UK-based sequencing service provider for your laboratory needs

We are here to help you answer your research questions by providing an end-to-end next generation sequencing (NGS) service.  Flexibility and quality are paramount, with a solution to fit your laboratory needs and goals.

DNA extraction

DNA extraction

Quality control

Quality control

Library preparation

Library preparation

NGS sequencing

NGS sequencing

Bioinformatics analysis

Bioinformatics analysis

NGS Services

E

DNA extraction

E

Sequencing customer made Illumina libraries

E
Tumour/liquid biopsy sequencing – targeted cancer detection screen
E

Bioinformatic analysis

Sample types accepted

Extraction service: (submission guidelines)

N

Blood and plasma

N

Saliva

N

FFPE tissue – slides, curls, macrodissection from pre-marked slides

N

Urine

Sequencing:

N

DNA – gDNA, cfDNA, FFPE

N

Illumina compatible libraries

Bioinformatic analysis

Options:

5

fastp/FastQC and MultiQC reports

5

Germline genotype characterisation (small variant and CNV)

5

Tumour only or paired normal somatic variant characterisation with initial variant annotation and cohort analysis 

5

Shallow WGS CNV characterisation with tumour content estimation

Data transfer

Secure cloud-based data transfer:

5

Secure data hosting in DNAnexus for easy retrieval via web portal or CLI

5

Hassle free data transfer straight to your AWS (Amazon) S3 buckets

NGS technology

5

Next generation sequencing DNA library preparation: Cell3™Target

5

Sequencing: Illumina platforms

Ordering information

5

Sequencing services

Informed Genomics mission

Whole genome sequencing

As a non-targeted sequencing approach WGS captures the genetic information from entire genomes. Benefits of this include the detection of disease related variants, the discovery of novel genes and tracing inherited disorders especially in non-coding regions of the genome. This is not species specific, so although commonly associated with humans, it’s equally as useful within plant, veterinary and microbial research.

Whole exome sequencing

Targeting all the protein coding regions in the human genome, WES offers a cost-effective alternative to WGS. It is the most comprehensive tool for detecting the genetic variations underlying cancers, Mendelian diseases, and complex human disorders.

custom design panel
Informed Genomics mission

Tumour profiling

Targeted sequencing panels to detect genes and mutations specific to known cancer phenotypes. A panel of 524 oncogenes for profiling and stratification of common human cancers and response prediction to immunotherapy.

Custom design your own NGS panel for any species

Individual projects may have unique requirements for the specific regions of the genome being targeted. We can help you design your own custom panel focusing on your research question.

5

Complete design flexibility with Cell3™ Target panels

5

Personal and bespoke service to ensure aims of the project are met

5

To collaborate with us on your own design, complete our service request form and we’ll be in touch

RNA sequencing

RNA sequencing

Our customisable RNA sequencing service is designed support your research with workflow flexibility and choice of assay, whether you want to gain a comprehensive view of the transcriptome, or target on gene expression.

Customer feedback

3

Kasia from CoSyne Therapeutics:

What specific aspects of our services do you find the most beneficial?

“We mostly used Informed Genomics for sequencing of small projects using NextSeq2000. In the start-up environment what is most important for us is speed of data delivery and that’s what we can always count on while working with your team. With other sequencing providers waiting time is usually 4 or more weeks which makes our projects (especially if they are pilots) difficult to deliver on time but we feel like we can always count on you to get sequencing data quickly and with good quality.

 

Also Louise and Jana has been very helpful, friendly and professional while assisting in choosing right options and troubleshooting issues.

 

Feedback that I also received from our bioinformaticians is that it is absolutely painless and very efficient experience in getting data via DNA Nexus (what they can’t say about other sequencing providers) and they are always happy when I mentioned that particular project will be done with Informed Genomics.”

How would you describe your overall experience with our team?

“Absolutely excellent! We don’t have a single thing that we would change about you or could complain about. Please keep this fantastic service for the future as we really like working with you.”

How has Informed Genomics helped contribute to your work?

“As I mentioned in first question, time is the huge value for our projects so Informed Genomics enormously contributed to our work by providing us sequencing data quickly and in easy to access way. Any minute that our bioinformaticians save on obtaining data from the providers – is already beneficial to whole company. Adding to that, weeks saved by getting data quicker than in other sources – is making us able to achieve goals much quicker.”

Would you recommend Informed Genomics to others? If so, why?

“Yes, absolutely. All the conversions we previously had with your representatives showed that you know your field very well, you are very professional and you are able to help make the best decisions when it comes to Genomics. I will be definitely recommending Informed Genomics to anyone who looks for support in library preparation or sequencing.”

What other customers are saying about Informed Genomics:

Ebun Omoyinmi from UCL

“In 2020, our research team began utilizing the whole exome sequencing (WES) service provided by Nonacus, which has now been transferred to the sister company, Informed Genomics. We made the decision to transition from performing targeted enrichment capture in our lab to WES due to the pandemic and the discounted competitive pricing offered by Informed Genomics. Since then, we have consistently received high-quality sequencing data, even for challenging high ‘GC’-rich regions, for approximately 200 samples. The rapid turnaround time provided by Informed Genomics has been particularly valuable for processing urgent samples. The staff members at Informed Genomics are friendly, skilled, and helpful in troubleshooting any issues that arise. They have readily assisted us with data analysis and have customized a bioinformatic workflow to meet our specific requirements. We are highly satisfied with their services and intend to continue using Informed Genomics for our sequencing needs.

Maciej from University of Edinburgh

“It’s great to work with Informed Genomics. We use them for a variety of projects and were always impressed by their professionalism and attention to detail. I would highly recommend their services!”

Connor Woolley from the Tomlinson Group

“Our research group worked with Informed Genomics to carry out targeted sequencing of FFPE samples from a cohort of cancer patients that underwent preoperative chemoradiotherapy. We wanted to explore how the genetics of these cancers changed during treatment and needed high sensitivity to be able to detect any residual tumour cells in excellent responders. We chose Informed Genomics due to their experience sequencing FFPE material and ctDNA which also requires very high sensitivity and opted to use a custom targeting panel to cover all of our genes of interest. The team were incredibly helpful and knowledgeable throughout each step of the process, from panel design to any troubleshooting along the way, and we would certainly recommend them going forward.”

Request a service quote

DNA/RNA extraction required

Unit 5
Quinton Business Park
11 Ridgeway
Quinton
Birmingham
B32 1AF