Whole genome sequencing

Gain a deep understanding of the whole genome, by investigating both coding and non-coding regions

 

A straightforward and robust whole genome sequencing (WGS) workflow:

DNA extraction

DNA extraction

Quality control

Quality control

Library preparation

Library preparation

NGS sequencing

NGS sequencing

Bioinformatics analysis

Bioinformatics analysis

Informed Genomics are a UKAS accredited, ISO15189 approved, company with our laboratories based in Birmingham, UK, focused on providing a premium next generation sequencing service.

Whole genome sequencing

service overview

Purpose

  • Research

DNA extraction: (sample submission information)

  • Whole blood (fresh)
  • Plasma
  • Saliva

DNA direct into library preparation:

  • Genomic (gDNA) high molecular weight from any species

Sequencing only:

  • Illumina compatible libraries

Contact us to find the best solution for you

DNA input

  • gDNA 10-100 ng

Technology

  • NGS library preparation: Cell3™ Target
  • Sequencing platform: Illumina

Indexing options

  • 384 indexing strategy
  • Unique dual indexing (UDIs)  
  • Unique molecular indexes (UMIs)

Data transfer

Secure, cloud-based data transfer:

  • fastp/FastQC files 
  • Secure data hosting in DNAnexus for easy retrieval via web portal or CLI
  • Hassle free data transfer straight to your AWS (Amazon) S3 buckets

Quality assurance

  • UKAS accredited, and ISO15189  approved laboratories

Why choose Informed Genomics?

Highly scalable

Submit one sample or hundreds

Flexible service packages

Take advantage of our DNA extraction option to streamline your project from start to finish 

Low DNA concentrations

Inputs from as little as 10 ng gDNA 

Built-in error suppression

Automatic inclusion of UMIs and UDIs during library preparation remove PCR error and index hopping factors 

WGS coverage to suit your application

  • <10x (shallow/low pass)
  • 30x (germline variant coverage)
  • ≥100x (ultra-deep)

Customer feedback

3

Kasia from CoSyne Therapeutics:

What specific aspects of our services do you find the most beneficial?

“We mostly used Informed Genomics for sequencing of small projects using NextSeq2000. In the start-up environment what is most important for us is speed of data delivery and that’s what we can always count on while working with your team. With other sequencing providers waiting time is usually 4 or more weeks which makes our projects (especially if they are pilots) difficult to deliver on time but we feel like we can always count on you to get sequencing data quickly and with good quality.

 

Also Louise and Jana has been very helpful, friendly and professional while assisting in choosing right options and troubleshooting issues.

 

Feedback that I also received from our bioinformaticians is that it is absolutely painless and very efficient experience in getting data via DNA Nexus (what they can’t say about other sequencing providers) and they are always happy when I mentioned that particular project will be done with Informed Genomics.”

How would you describe your overall experience with our team?

“Absolutely excellent! We don’t have a single thing that we would change about you or could complain about. Please keep this fantastic service for the future as we really like working with you.”

How has Informed Genomics helped contribute to your work?

“As I mentioned in first question, time is the huge value for our projects so Informed Genomics enormously contributed to our work by providing us sequencing data quickly and in easy to access way. Any minute that our bioinformaticians save on obtaining data from the providers – is already beneficial to whole company. Adding to that, weeks saved by getting data quicker than in other sources – is making us able to achieve goals much quicker.”

Would you recommend Informed Genomics to others? If so, why?

“Yes, absolutely. All the conversions we previously had with your representatives showed that you know your field very well, you are very professional and you are able to help make the best decisions when it comes to Genomics. I will be definitely recommending Informed Genomics to anyone who looks for support in library preparation or sequencing.”

Get in touch

Unit 5
Quinton Business Park
11 Ridgeway
Quinton
Birmingham
B32 1AF